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We next performed a structural similarity search across our in-house compound collection, as well as on commercial small-molecule libraries (1,000,000 compounds) and identified 141 additional hits, which were screened in the high-throughput activity assay at a single concentration of 10 M

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Additionally, molecular signals such as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) can cross into the circulation, potentially impacting both the microbiota and CNS function

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