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These doses must be titrated against side effect tolerability, as excessive HGH produces acromegaly-like changes and substantial system-wide effects

Figure 1 3 Typing and diagnosis of diabetic cardiomyopathy and its pathogenesis 3.1 Typing and diagnostic criteria of diabetic cardiomyopathy The histological features of DCM include myocardial collagen deposition, myocardial hypertrophy, and fibrosis ( The minimum diagnostic criteria for DCM include LV diastolic dysfunction and/or reduced LV ejection fraction (LVEF), LV hypertrophy, and interstitial fibrosis and can be divided into three stages: early, advanced, and end

This process is accomplished by methyltransferases using S-adenosyl-methionine (SAM), as the methyl donor[78]

Encapsulated in liposomes, it can better penetrate cells, providing strong antioxidant protection, reducing cell damage from oxidative stress