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Lower tirzepatide doses (510mg weekly) reduce GI side effect burden while still providing meaningful appetite suppression, allowing researchers to maintain protocol adherence without the nausea and vomiting that causes 1015% of subjects to discontinue at higher doses

To investigate the role of ROS and the mechanism of action of DPI in MNA cells, we employed a widely and commercially available mitochondria-targeted antioxidant, mitoquinone mesylate (MitoQ)