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116 Additional genes, such as CYBA , GSTP1 , EPAS1 , HSPA1A , HSPA1B , TIMP3 , SFTPA1 , and SFTPA2 , have also been implicated in HAPE development

Cynaroside intervention significantly improved these phenomena, suppressed mouse weight gain, reduced TC, TG and LDL-C levels in serum, inhibited adipocyte hypertrophy and reduced the level of inflammatory factors (Yang et al., 2025)