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doi: 10.1016/j.tcb.2018.02.001 72 Davan-WettonCSAPessolanoEPerrettiMMontero-MelendezT

The Ni 2+ ion serves as the binding site for His-tagged proteins to the agarose beads

If the methyl group is replaced by the chlorine atom, then this compound (chlorpropamide) achieves a longer half-life (1215 hrs) as compared to tolbutamide [21]