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Although naturally occurring, it is the least stable of the four types of B12 outside the human body and does not translate well into a tablet-based supplement

That variety matters because it allows treatment to be tailored to the individual rather than forcing every patient into the same approach

From a research-design standpoint, this means any future genotype-by-form study must carefully hold dose and frequency constant, or those larger effects will swamp the subtler form-by-genotype signal it is trying to detect

TB-500 has a slight edge, since Thymosin Beta-4 has been investigated in two Phase 2 trials in patients with chronic ulcers