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In these districts GSH is predominantly in the reduced form except for endoplasmic reticulum where the oxidized form is mainly present being necessary for the correct folding and secretory pathway of proteins (Hwang et al., 1992)

Given these dual roles, precise regulatory systems are necessary to maintain Mn homeostasis in vivo, and Mn transporters act as the key executors of such regulation 32,33

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While most glutathione medication interactions are mild, there is a risk that glutathione supplementation could lower a medications effectiveness