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The miRNA prodrugs also increased apoptotic gene expression in response to chemotherapy (Supplemental Figure 10F)

Consistent with these findings, the levels of inflammatory factors TNF- and IL-6 in the synovial fluid of the RBC@SeMSN@Uri-treated mice significantly decreased from 237.6 pg/mL and 396.0 pg/mL in the model group to 147.4 pg/mL and 235.0 pg/mL, respectively, nearly returning to normal levels (Figures 6H, I)

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They secrete soluble mediators, known as the senescence-associated secretory proteome, which induces adjacent cell damage and stimulates fibrosis