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The specific methodology involved the following steps: (1) Retrieve the high-resolution structures of the Tier 1 target proteins from the Protein Data Bank (PDB), import them into PyMOL, remove solvent molecules and small organic molecules, and add hydrogen atoms and export the structures in PDBQT format

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High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms

STAT3-mediated SMAD3 activation underlies oncostatin M-induced senescence