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Mechanistically, under the action of ultrasound, this system not only exhibits traditional CAT-like and POD-like activities to modulate ROS levels but also facilitates macrophage polarization from the pro-inflammatory M1 phenotype to the regenerative M2 phenotype [Figure 9C]

its learning which terrain a mechanism belongs to, so we can swap a drug or a nutrient and still get the same systemic correction

Non-antibiotic compounds associated with humans and the environment can promote horizontal transfer of antimicrobial resistance genes

Secondly, Holo-Lf also alleviates tumor hypoxia by decomposing the abundant H 2 O 2 in the TME into oxygen, thereby reversing radiotherapy resistance [267]