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Here, we provide a comprehensive overview of the complex interplay between Mn metabolism and various diseases, integrating insights gleaned from environmental Mn toxicity, inherited Mn transportopathies, and their molecular mechanisms

However, the potential side effects of NRF2 activators and ferroptosis inhibitors have not been thoroughly evaluated

However, the UPS undergoes Kla in SLE 93 , which impacts UPS activation mediated by the metabolic switch, resulting in an inability to clear mitochondria by autophagy and a consequent increase in these organelles in mature RBCs