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Dysbiosis, inflammation, and gut-derived metabolites are all critical factors in the progression of kidney disease

doi:10.1038/154667b0

A growing body of evidence highlights the crucial role of lactylation in various diseases, particularly in tumor-related and IRI-related conditions associated with elevated lactate levels [18,19,20,21,22]

PPARs and several other systems regulate lipophagy at the highest level by controlling downstream factors to ensure that free fatty acids levels in a cell are optimal [106] according to a general rule that states that nutrient starvation stimulates autophagy and their abundance inhibits the process