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But when the same receptor gets hit with the same signal nonstop, a chain of events unfolds: The cell marks the receptor with a chemical tag (phosphorylation) A protein called beta-arrestin grabs the tagged receptor and shuts down further signaling The cell pulls the receptor inside (internalization) Some receptors get recycled and put back on the surface

This balance between necessary and harmful inflammation is what allows healing to proceed without compromising defence

In cases where the cause remains unclear, treatment fails, or there is significant neurological involvement, referral to haematology or gastroenterology may be appropriate for further investigation