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Time-course analysis was conducted using two approaches: (i) Hotellings T statistic, combined with a multivariate empirical Bayes method, as implemented in the Timecourse R package [36], and (ii) a composite method based on three polynomial regression models, as implemented in the RolDE R package [37]

These ocular delivery challenges impede the translation of ferroptosis-targeted therapies, emphasizing the urgency for novel targeted and sustained drug delivery systems

After 12 weeks of supplementation, the checklist of migraine indicators including migraine attacks/month, migraine days/month, and headache severity was completed, and serum concentrations of magnesium and l-carnitine were measured by atomic absorption spectrophotometry and enzymatic UV test, respectively