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Immunostimulatory nucleic acids are considered to be non-sequence specific when it is not required that they specifically bind to and reduce the expression of a target polynucleotide in order to provoke an immune response

However, another work had previously shown that lowering glycolytic flux, which physiologically happens in parallel to ketone body utilization, negatively regulates BDNF expression (Garriga-Canut et al., 2002