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15 Patients usually begin one to two weeks before their quit date, with a one week dose escalation period, followed by 11 weeks of maintenance treatment:* 15 Step 1 set a quit date Step 2 initiate varenicline one to two weeks before this quit date, initially at a dose of 500 micrograms, once daily, for the first three days Step 3 increase the dose to 500 micrograms, twice daily, for four days Step 4 increase the dose to 1 mg, twice daily Step 5 most patients should continue with this maintenance dose for 11 weeks

Post-discharge instructions may be hard for patients to follow, either due to a lack of understanding or difficulty making changes due to deeply ingrained habits

The perceived social benefits described in this study have similarity with the concept of functional beliefs by Yong et al