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Similarly, in hepatocytes exposed to lipotoxic stressors, zinc supplementation reduces cytotoxicity by mitigating ER stress and enhancing antioxidant defense, demonstrating its capacity to preserve proteostasis and limit inflammatory responses 178

Inhibition of cell growth and induction of apoptosis by piperlongumine were also reported in human melanoma cells, via ROS-mediated mitochondria disruption and JNK (p-Jun N-terminal kinase) pathway [90]

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Application of cold plasma technology on plants Agriculture with low content of fertilizers and chemicals has been widely attracting attention