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Owing to their special physicochemical properties, nanomaterials can be tailored at the molecular level for drug delivery or can reasonably mimic the morphology and function of cells and tissues for tissue regeneration [98, 99]

In OA animal models, oral or local administration of NAC has been observed to mitigate cartilage damage and pain, closely tied to its role in sustaining GSH levels and inhibiting ferroptosis (92)

Currently, our knowledge of the effects of the drugs already available on the market that target mucin is extremely limited

Meanwhile, the 4-week heat pain results also suggested that GlyNAC intervention could promote the recovery of sensory function in rats to some extent