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PMID: 38675983 Biotechnol J Engineering a Membrane-Anchored CreER Recombinase With Reduced Basal Activity for In Vitro Recombination

Adams RP

Possible explanations could be either rapid internalization of the anti-TNF- VNAR-C4 upon binding to tmTNF- or because the smaller contact surface (epitope) on TNF- recognized by this VNAR-C4 is conformationally different in both the transmembrane and soluble versions of TNF-

a meta-analysis found pre- versus post-treatment effect sizes of 1.55 for clomipramine relative to a range of 0.67 for imipramine and 0.11 for desipramine