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The variable domains of naturally occurring heavy and light chains each comprise four FRM regions (FR1 , FR2, FR3, and FR4), largely adopting a -sheet configuration, connected by three hypervariable regions, which form loops connecting, and in some cases forming part of, the -sheet structure

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Interestingly, a recent study raised controversies about the role of mitophagy in ferroptosis by indicating that mitophagy could protect renal tubular epithelial cells from ferroptosis in cisplatin-induced acute kidney injury (AKI) [77]