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Further, to what we already showed [i.e., testosterone increased IGF-1 gene expression during RET (Gharahdaghi et al., 2019)], both testosterone and estrogen blunted IGF-I feedback-dependent inhibition of GH secretion (Veldhuis et al., 2004, 2005)

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[9] Behavioral reinforcement of food intake [edit] It is well-characterized that activating the growth hormone secretagogue receptor with ghrelin induces an orexigenic state, or general feeling of hunger