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Thus, iron accumulation and metabolism disorder after TBI may lead to secondary axonal injury and cognitive dysfunction through inducing oligodendrocyte apoptosis

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For example, we showed that the incorporation of 2 H -azirine and -nitrostyrene electrophiles into ligands targeting EGFR L858R/T790M/C797S and BRD4 resulted in potent degraders that recruit NEDD4 and TRIM28 48,49 , respectively, leading to proteasome-dependent protein degradation

Ultimately, it has been argued that the role of angiogenesis in the increased survival rate of ALS is likely regulated by NF- activation (Thakur et al