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Chemical synthesis via SPPS is crucial for these modifications, enabling precise sequence control, improved stability, and exploration of structure-activity relationships ( 4.1 Incorporation of unusual amino acids Chemical synthesis of AMPs offers advantages over natural extraction, enabling precise sequence modification via solid-phase peptide synthesis (Pazgier et al., 2006

calorie-controlled) low-carbohydrate diets improve both glycemia [52-56] and hypertension, [54-56] with the studies lasting four months, [53] one year, [54] and then two years, [56] respectively