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pylori ATCC 43504), while polyphenols and flavonoids such as quercetin, catechin, and luteolin inhibit urease and DNA gyrase act at MIC values of 1632, 64128 and 3264 g/mL, respectively (Huang et al., 2024)

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Synthetic lethality was observed with loss of Fe-S cluster assembly genes, such as NFS1 cysteine desulfurase and HSPA9, and the Fe-S cluster transporter ATP binding cassette subfamily B member 7 (ABCB7), while the abrogation of mitochondrial Fe-S cluster-loading factors such as glutaredoxin 5 (GLRX5) and iron-sulfur cluster assembly factor IBA57 conferred resistance

The enzymes which have participated in these essential detoxification mechanisms comprise catalase, monodehydroascorbate reductase, superoxide dismutase, ascorbate peroxidase, glutathione reductase, dehydroascorbate reductase, guaiacol peroxidase [151]