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Studies have shown that NADK activity mediates response mechanisms to regulate PSI biosynthesis (Ji et al., 2022)

HIFs are vital at all key stages of metastatic dissemination, for example, processes such as local migration within the tumor and invasion of the surrounding stromal tissue by inducing an EMT-like process and remodeling the extracellular matrix [228]

doi: 10.1016/j.xcrm.2021.100437 29

It was noted earlier that NAPQI is highly electrophilic in nature which means that there should be positively charged regions on the other side of NAPQI (which is in fact found on the other side of the molecule