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Importantly, absence of p21 promotes a development of spontaneous tumors in mice [89] and mutations in this gene were shown to correlate with PTX resistance in mammary cells [90]

In 1980, Mezei and Gulasekharam introduced liposomes for the treatment of skin diseases [122]

Crude and adjusted rates were analyzed, and temporal trends were evaluated using logistic regression with orthogonal polynomial contrasts for each year