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In cultured cells, curcumin has been shown to inhibit cytokine-induced NF-B activation at multiple steps, blocking IB degradation, nuclear translocation of NF-B (p65/RelA), and NF-B DNA binding, ultimately reducing downstream expression of inflammatory mediators such as interleukins and chemokines (Peng et al., 2021)

Yunus proposed that fibromyalgia involves a central nervous system amplification of pain signals, an insight that later guided regenerative approaches targeting neural glial cells

Interestingly, there was a significant reduction in BDNF-AS RNA methylation at m6A sites in adolescent-onset AUD but not in late-onset AUD

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