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10.3389/fimmu.2018.01782 Front

The affinity of tapentadol for the MOP receptor is 50 times lower than that of morphine, which, when counterbalanced by its activity on noradrenaline modulation, results in an improved tolerability profile, lower rate of tolerance development, lower abuse potential, and efficacy in both nociceptive and neuropathic pain [46, 47]