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[Wiley] 22

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In summary, our findings offer insights into the neural mechanisms of opioid-induced constipation and help clarify the limited efficacy peripheral opioid receptor antagonists in treating opioid-induced constipation patients

Materials and methods Animals and treatment Thirty Wistar rats were obtained from the Central Animal House of the Faculty of Medicine of Ribeiro Preto, University of So Paulo, after approval by the institution's Ethics Committee of Animal Experimentation