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For instance: decreasing androgen receptor expression

Pharmacogenetics 2(2):7377 Guengerich FP (1990) Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs

However, the reported lack of binding of either the HECT or RING E3 ligases to the p63 DBD (Figure 1) initially suggested that p28 had no direct effect on the ubiquitination of p63