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References Abbas H, Gad HA, Khattab MA, Mansour M (2021) The tragedy of Alzheimers disease: Towards better management via resveratrol-loaded oral bilosomes

RNA concentration and purity were assessed using a NanoDrop ND-1000 spectrophotometer (NanoDrop Technologies, Inc.)

Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20