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(2018) found melanoma cells could be induced to dedifferentiated by supplying IFN- and tumor necrosis factor-(TNF-) to melanoma culture to mimic the inflammatory tumor microenvironment and such microenvironment is associated with increased susceptibility to ferroptosis induction

Gujral, N., Lbenberg, R., Suresh, M

For the new study, published in Science Translational Medicine , Martin Berg, a cell biologist at the University of Gothenburgs Sahlgrenska Cancer Center in Sweden, and his colleagues decided to look at melanoma because rates have been increasing and because the cancer is known to be sensitive to the effects of free radicals

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