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Tissue specificity of MR regulatory pairs The MR pairs of three tissues were divided into seven categories based on the sharing across the three tissues, including three tissue-specific, three pairwise sharing, and one all-sharing group, and the Venn diagram was plotted to display the intersection of regulatory pairs determined for each category

Future research should continue to explore the mechanisms underlying the actions of melatonin and its potential applications in clinical settings

Binding of BRD4 ET to ASXLs is conserved ASXL1 and homologous ASXL2 and ASXL3 were identified as mutually exclusive components of the PR-DUB complex 1,29 , and all contain similar but not identical ET-binding sequences (IRIQL in ASXL1, LKIPV in ASXL2 and LKIQL in ASXL3) (Supplementary Fig

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