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In addition to containing sequences common to those of other SLC39A transporters, this subfamily contains a highly conserved putative metalloproteinase motif in the fifth transmembrane domain (TM-V), which is highly similar to the active site of metalloproteinases 94,95

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It continues to be investigated in diverse areas such as acute respiratory distress syndrome, toxicology, AIDS, aging, oncology, and liver disease

Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation