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The high-purity raw collagen, vacuum evaporation process achieving high collagen content, increased chemical-crosslinker-to-collagen ratio and optimized photochemical crosslinking, along with other key biomaterial properties, significantly differentiates the BPCDX from previous materials tested in humans (see Supplementary Table 1 for a detailed comparison)

Belda-Palazn, B

Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Stevenson and Thornton, 2007)

The various forms of XY and X/XY DSD have a variable risk of developing a gonadal germ cell cancer