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In addition, through transplantation of PSP-associated intestinal flora, could also increase the expression of TJ proteins, reduce LPS, and inhibit inflammatory responses in the hippocampal area, and alleviate depression, effects similar to that of direct administration of PSP (Table 2)

Major Criteria Skin hyperextensibility, with velvety skin texture and absence of atrophic scarring Generalized joint hypermobility, with or without recurrent dislocations (most commonly shoulder and ankle) Easily bruisable skin/spontaneous ecchymoses Minor Criteria Foot deformities (broad/plump forefoot

Dormancy Period: Up to many years depending on the related vector

Relying on the resource advantages of R