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Furthermore, the discovery could not have been obvious because the inventors of the 779 Patent engaged in extensive experimentation, involving much failure and they were shocked and concerned by how little ABUK remained in their final product

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Finally, we demonstrated that the previously unknown transsulfuration reaction from glutathione for -Glu-Ser-Gly synthesis was also present in iBMDM cells through [U- 13 C]-cysteine labeling experiment (Supplementary Figs