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Catalpol ameliorates diabetes-induced testicular injury and modulates gut microbiota

(Shengma) has been shown to significantly elevate tight junction proteins Claudin-1, Occludin, and ZO-1, as well as the MUC2, through inhibition of PI3K/Akt/NF-B signaling pathway to enhance the intestinal mucosal barrier to reduce pathogen invasion (Wu et al., 2025)

We reported earlier that ACD in older humans is associated with glutathione (GSH) deficiency, oxidative stress (OxS), mitochondrial dysfunction, glucose dysmetabolism and inflammation, and that supplementing GlyNAC (glycine and N-acetylcysteine) improved these defects

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