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These transcriptional changes indicate enhanced apoptosis and reduced cell proliferation, consistent with the effects of severe ER stress

While most studies have focused on SLC7A11-mediated cystine import, this study suggests that SLC7A11-mediated glutamate export can cross-talk with and modulate tumor immune systems, which in turn influence tumor growth and response to cancer therapies

Conversely, melatonin supports physiological estradiol synthesis by preserving aromatase activity and maintaining redox stability within granulosa cells (197)