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For example, prolonged ferroptosis inhibition may promote tumorigenesis (by suppressing cell death in pre-malignant cells) or exacerbate other pathological processes (e.g., fibrosis) in ADPKD kidneys, risks that require rigorous evaluation in long-term animal models

10.1111/aogs.14864 [DOI] [PMC free article] [PubMed] [Google Scholar] Guillemin L., Hofstede J., Anderson T., Walkeden H., Schellenberg K., Kang E., et al

After 1 day, all hydrogel groups supported comparable cell proliferation, and over time, a progressive increase in cell growth was observed in all groups

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