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257 WakitaS.IzumiY.NakaiT.AdachiK.Takada-TakatoriY.KumeT.et al (2014)

This is expected to be the first mRNA tumor vaccine on the market

Only stereoisomers with an R -configuration in position 2 ( RRR , RSR , RRS , RSS ) are considered biologically active and meet human vitamin E requirements