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Some studies have proposed the hypothesis that the increase of mannose level in the CSF of PD patients may be directly related to the decreased MBL level that leads to decreased mannose binding, thus increasing the accumulation of free mannose in the CSF

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In MPTP-induced monkey model of PD, clioquinol significantly alleviated both dyskinesia and non-motor impairments, concomitant with a reduction in iron accumulation and ROS levels in the SN (228)

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