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In addition, IL4R is highly expressed in M2-polarized, protumoral TAMs compared with M1-polarized, antitumoral macrophages, making IL4R a potential target for targeted drug delivery to TAMs 31,32

This phenotype was reminiscent of IRE1 -/- mice where the percentage of CD4 + T cells showed a trend towards declining, and the percentage of CD8 + T cells was significantly diminished

Theres also data showing that CD20 inhibitors such as Kesimpta can cause a temporary reduction in B-cell and other white blood cells in infants exposed to these medications during pregnancy