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Contrary to alternative method based on a competitive hypothesis, GSVA is based on self-contained null hypothesis which analyzes each gene set in isolation, assessing differential expression of the gene set without comparing to a background [62, 63]

Ruiz AG, Casafont F, Crespo J, Cayon A, Mayorga M, et al

Caffeine metabolism: A matter of individual biology Variations in genes such as CYP1A2 and ADORA2A explain much of caffeines interindividual variability., CYP1A2 determines how quickly caffeine is cleared from the bloodstream, while ADORA2A influences sensitivity to adenosine receptor blockade in the brain

ESMO World Congress on GI Cancer 2017 28(suppl_3), 2017