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10.1016/j.biopha.2022.113568 47 LiX.TangJ.MaoY

Diabetes Mellitus Diabetes mellitus (DM) is metabolic disorder presenting with a high blood-glucose level (hyperglycemia), polyphagia, and polydipsia, and it results from either an autoimmune process that leads to the destruction of pancreatic cells resulting in absolute insulin deficiency in type 1, or, in contrast, type 2 DM, which involves a combination of insulin resistance and a relative insulin deficiency [89]