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Always perform a patch test before applying

This impaired clearance would also be compounded by exogenous copper downregulating LRP1 expression (Singh et al., 2013), that could further impede CNS clearance of LRP1 ligands such as Tau or A

The medication is available in multiple formulations to accommodate different patient needs and treatment protocols, with dosing typically following a gradual titration approach to optimize therapeutic benefits while minimizing adverse effects

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