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QD community oral or SC MOTS-c Daily SC, often 5 days on / 2 off AOD-9604 Daily SC Attribute Max studied dose SLU-PP-332 50 mg/kg BID (mouse, 28 days) MOTS-c 5-15 mg/kg (mouse) AOD-9604 1-5 mg/day in human Phase 2 Attribute Peak efficacy signal SLU-PP-332 ~25-30% fat-mass reduction in DIO mice over 28 days MOTS-c Improved insulin sensitivity in aged mice AOD-9604 Modest fat-loss signal in human Phase 2

It is involved in the metabolism of human somatic cells, aects the synthesis and regulation of DNA, and participates in the synthesis of fatty acids and BMC Pregnancy and Childbirth *Correspondence: Ying Zhang [email protected] Changjun Zhang [email protected] 1Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Peoples Republic of China 2Hubei Clinical Research Center for Reproductive Medicine, Shiyan, Peoples Republic of China 3Biomedical Engineering College, Hubei University of Medicine, Shiyan, Peoples Republic of China 4Biomedical Research Institute, Hubei University of Medicine, Shiyan, Peoples Republic of China Abstract Purpose To investigate whether vitamin B12 levels aect IVF-ET pregnancy outcomes

Cyanocobalamin (Vitamin B12): 1000 mcg