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Research protocols sometimes combine matrikine signals with broader gene modulators to address both the targeted collagen induction pathway and the broader tissue remodeling network simultaneously

3.2 Bidirectional regulation of lipid metabolism Lipid metabolism serves as a critical bidirectional regulator of CD4 + T cell differentiation, dynamically shaping the balance between pro-inflammatory Th17 cells and immunoregulatory Treg cells through integrated control of extracellular lipid uptake, intracellular synthesis, and FAO (90, 91)

Moreover, alteration of the administration order of Bu-Cy to Cy-Bu gives the same engraftment outcome but reduces the toxicity of the conditioning regimen both in patients and mice 59,60

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