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However, studies show that the diagnosis of cytology and histopathology show a complete agreement in only 30% of the cases

Hu B, Jin J, Guo A-Y, Zhang H, Luo J, Gao G

The cellular modulation and protein replacement therapeutic strategies involve mRNAs that encode a functional protein, which can be expressed in the target cell as an endogenous protein, a functional foreign protein or proteins used for gene editing or cellular modulation (Figure 7