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Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome (PNAS) Oxidative stress is a shared characteristic of ME/CFS and Long COVID (PubMed) Augmented Glutathione Absorption from Oral Mucosa (Journal of Clinical Medicine) The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review (PMC) Efficacy of N-Acetylcysteine in ME/CFS (ClinicalTrials.gov NCT04542161)

Together, this multi-layer remodeling across the PFC, NAc, amygdala, and hippocampus provides a mechanistic bridge linking depressive and addictive pathology (Fig